Polyketide natural products are the ideal starting points for drug discovery. Over 10,000 are known; 1% have drug activities (5x the average for any other class of natural products) over a broad range of therapeutic applications.
Scarcity in nature, lack of a sustainable supply, and highly complex structures that impede chemical synthesis, are the main challenges for clinical development.
From simple to intricate in few steps
The Chiral Carbon Catalog Platform (CCC)
Stereotetrad arrays are common structural features of polypropionate polyketides. They are very challenging targets to synthesize. Stereocontrol, in particular, is not trivial.
TO DATE, THE CCC IS THE ONLY KNOWN METHOD FOR SCALE UP SYNTHESIS OF STEREOTETRADS.
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The advantages of the CCC are attributed to our patented use of the versatile vinylsulfone group, the substrate-directed stereospecificity, in addition to reaction conditions that are highly optimized for large scales.
Hundreds of grams to kilograms
All 8 possible relative stereochemistries of stereotetrad building blocks (16 if absolute stereochemistry is considered)
Key steps are as easy as..
From inexpensive to invaluable
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