From inexpensive to invaluable
The Chiral Carbon Catalog Platform (CCC)
The Polypropionate Polyketide class of compounds is an ideal starting points for drug discovery with activities over a broad range of therapeutic applications.
The high complexity of their structures, that impedes chemical synthesis, is a main challenge for clinical development.
Hundreds of grams to kilograms
Stereotetrad arrays are common structural features of polypropionate polyketides. They are very challenging targets to synthesize. Stereocontrol, in particular, is not trivial.
TO DATE, THE CCC IS THE ONLY KNOWN METHOD FOR SCALE UP SYNTHESIS OF STEREOTETRADS.
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The advantages of the CCC are attributed to our patented use of the versatile vinylsulfone group, the substrate-directed stereospecificity, in addition to reaction conditions that are highly optimized for large scales.
All 8 possible relative stereochemistries of stereotetrad building blocks (16 if absolute stereochemistry is considered)
From simple to intricate in few steps
Key steps are as easy as..