Polyketide natural products are the ideal starting points for drug discovery. Over 10,000 are known; 1% have drug activities (5x the average for any other class of natural products) over a broad range of therapeutic applications.

Scarcity in nature, lack of a sustainable supply, and highly complex structures that impede chemical synthesis, are the main challenges for clinical development.

Industry Friendly

From simple to intricate in few steps

Common Feature

Time Efficient

Crystallize

Stir/Quench

The Chiral Carbon Catalog Platform (CCC)

Add

Cost Efficient

Stereotetrad arrays are common structural features of polypropionate polyketides. They are very challenging targets to synthesize. Stereocontrol, in particular, is not trivial.

TO DATE, THE CCC IS THE ONLY KNOWN METHOD FOR SCALE UP SYNTHESIS OF STEREOTETRADS.

Scalable

Ease of monitoring

Stereospecific

No chiral auxillaries

No column chromatography Crystalllizable intermediates

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The advantages of the CCC are attributed to our patented use of the  versatile vinylsulfone group, the substrate-directed stereospecificity, in addition to reaction conditions that are highly optimized for large scales.

Hundreds of grams to kilograms

All 8 possible relative stereochemistries of  stereotetrad building blocks (16 if absolute stereochemistry is considered)

Key steps are as easy as..

From inexpensive to invaluable

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