Industry Friendly

Hundreds of grams to kilograms

Stereotetrad arrays are common structural features of polypropionate polyketides. They are very challenging targets to synthesize. Stereocontrol, in particular, is not trivial.

TO DATE, THE CCC IS THE ONLY KNOWN METHOD FOR SCALE UP SYNTHESIS OF STEREOTETRADS.

Scalable

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Crystallize

Stir/Quench

Add

All 8 possible relative stereochemistries of  stereotetrad building blocks (16 if absolute stereochemistry is considered)

Key steps are as easy as..

From simple to intricate in few steps

Common Feature

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The Chiral Carbon Catalog Platform (CCC)

Cost Efficient

Time Efficient

Ease of monitoring

Stereospecific

No chiral auxillaries

No column chromatography Crystalllizable intermediates

The Polypropionate Polyketide class of compounds is an ideal starting points for drug discovery with activities over a broad range of therapeutic applications.

The high complexity of their structures, that impedes chemical synthesis, is a main challenge for clinical development.

The advantages of the CCC are attributed to our patented use of the  versatile vinylsulfone group, the substrate-directed stereospecificity, in addition to reaction conditions that are highly optimized for large scales.

From inexpensive to invaluable