From inexpensive to invaluable

Common Feature

Time Efficient

The Chiral Carbon Catalog Platform (CCC)

Add

Cost Efficient

Scalable

The Polypropionate Polyketide class of compounds is an ideal starting points for drug discovery with activities over a broad range of therapeutic applications.

The high complexity of their structures, that impedes chemical synthesis, is a main challenge for clinical development.

Crystallize

Hundreds of grams to kilograms

Stereotetrad arrays are common structural features of polypropionate polyketides. They are very challenging targets to synthesize. Stereocontrol, in particular, is not trivial.

TO DATE, THE CCC IS THE ONLY KNOWN METHOD FOR SCALE UP SYNTHESIS OF STEREOTETRADS.

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The advantages of the CCC are attributed to our patented use of the  versatile vinylsulfone group, the substrate-directed stereospecificity, in addition to reaction conditions that are highly optimized for large scales.

All 8 possible relative stereochemistries of  stereotetrad building blocks (16 if absolute stereochemistry is considered)

Stir/Quench

Industry Friendly

From simple to intricate in few steps

Key steps are as easy as..

Ease of monitoring

Stereospecific

No chiral auxillaries

No column chromatography Crystalllizable intermediates