3495 Kent Avenue, Suite E-100
From simple to intricate in few steps
Hundreds of grams to kilograms
The Chiral Carbon Catalog Platform (CCC)
All 8 possible relative stereochemistries of stereotetrad building blocks (16 if absolute stereochemistry is considered)
From inexpensive to invaluable
Copyright © 2016 Akanocure Pharmaceuticals, Inc.
The advantages of the CCC are attributed to our patented use of the versatile vinylsulfone group, the substrate-directed stereospecificity, in addition to reaction conditions that are highly optimized for large scales.
Stereotetrad arrays are common structural features of polypropionate polyketides. They are very challenging targets to synthesize. Stereocontrol, in particular, is not trivial.
TO DATE, THE CCC IS THE ONLY KNOWN METHOD FOR SCALE UP SYNTHESIS OF STEREOTETRADS.
Polyketide natural products are the ideal starting points for drug discovery. Over 10,000 are known; 1% have drug activities (5x the average for any other class of natural products) over a broad range of therapeutic applications.
Scarcity in nature, lack of a sustainable supply, and highly complex structures that impede chemical synthesis, are the main challenges for clinical development.
Key steps are as easy as..